Access Our Report: Analysis of TP63 CUT&Tag data from human bronchial epithelial cells

CUT&Tag (cleavage under targets and tagmentation) is a high-throughput method used to assay genome wide protein-DNA interactions. CUT&Tag can be used to map binding sites of transcription factors and identify changes in global binding patterns across different conditions.

TP63 is a master transcription factor which regulates gene expression in developmental processes and plays a key role in epithelial cell development. In a study by Liu et. al., 2025, Nat. Commun., CUT&Tag was used to assay TP63 binding in a human bronchial epithelial cell line, BEP2D, with and without overexpression of TP63. Additionally, TP63 was also assayed in a radiation-induced tumour cell line derived from BEP2D cells, BERP35T1. The BERP35T1 cell line was found to overexpress TP63. In this report, we have analysed the publicly available CUT&Tag dataset (GSE175860) to explore changes in TP63 (p63 protein) binding between these cell lines.

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