Dermatology
Fios is particularly experienced in research for skin diseases, including dandruff, atopic dermatitis and psoriasis as well as skin ageing and sun damage analysis. We have been involved in the European Commission Funded (FP7) project Microbes in Allergy and Autoimmunity Related to the Skin (MAARS), which investigated atopic dermatitis as a model for allergy and psoriasis for autoimmune disease.
How we can help your dermatology research
By combining our expertise in bioinformatics analysis with our extensive knowledge in the dermatology area, we can support your research at every stage of the drug development process throughout pre-clinical and clinical phases. Our bioinformatics services can help with:
- Differential profiling in skin diseases such as psoriasis and atopic dermatitis
- Methylation profiling
- Data from skin ageing experiments
- Target and lead identification and validation
- Identifying biomarkers for measurement of drug efficacy and mechanism of action
- Predicting biomarkers for stratification/classification of patient response to drug
- SNP genotype analysis & DNA sequence analysis for the detection of novel SNPs implicated in disease or response to drugs
Our bespoke solutions utilise state-of-the-art approaches, tailored to the data types and requirements of each project.
Selected projects we have helped with
- Evaluation of methylation levels at baseline against age as a continuous variable, adjusting for disease status
- Identification of precancerous markers in sun-damaged skin
- Fios Genomics participated in the MAARS (Microbes in Allergy and Autoimmunity Related to the Skin) FP7 project
The MAARS project focused on two skin diseases, atopic dermatitis and psoriasis. The aim of this project was to investigate how environmental and genetic factors could initiate inflammatory events, as well as how the dysregulation of both innate and adaptive immune response could lead to inappropriate responses leading to clinical symptoms of these skin disorders.
Selected Publications
- Microbe-host interplay in atopic dermatitis and psoriasis
- Stress perception impacts on clinical signs of skin ageing and modifies the epigenome
- A multi-tissue age prediction model based on DNA methylation analysis
For more publications, visit our dedicated Publications page.
Getting Your Data Ready For Analysis
We can analyse:
- Recent data, generated within your own laboratory or that of a 3rd party provider
- In-house historic data
- Data sourced from the public domain.
While we prefer to receive data in the raw format (eg .CEL files) we can also receive pre-normalised files.
If you have yet to generate the data, we can help by arranging for the generation of your data through one of our preferred laboratory service partners. Alternatively, we are able to source and mine data from available databases. We are happy to work with you at every stage of your study to ensure the best outcome for your research.
Data Analysis Report for Dermatology
Our team has created a sample report featuring an analysis of RNA sequencing (RNASeq) dataset GSE47944 obtained from the NCBI GEO website.
The aim of the study featured in the report was to identify genes and pathways associated with psoriasis and the response of psoriatic skin to modulation of the AhR.
Our Reports
Our analysis reports at Fios are provided as an HTML link hosted on our secure server. The secure link leads the user to a password-protected HTML document which is clickable, searchable and dynamic. This format allows you to easily interrogate and explore your data. Additionally, all methods, tools and thresholds are fully documented within the report.
At Fios Genomics, we are completely data driven. Whatever your research area, we offer support at every stage of your research and for different purposes:
Discovery
Selecting the correct targets and/or the correct indication is essential for development success. We help support the process with robust analysis of historic or new data.
Preclinical Research
We help in experimental design and statistical analysis and guide our clients in making informed decisions during the preclinical stage.
Clinical
Research
We offer a comprehensive analysis approach for augmenting clinical trial outcomes, ensuring you get the most information out of your research.
Drug Repurposing
We have strong experience with identifying in silico new potential indications for existing drugs, reducing the cost and time of downstream wet lab validation.
