Analysis of Hi-C data from human bronchial epithelial cells

Hi-C is a high-throughput technique used to capture genome-wide chromatin conformations and elucidate interactions between genomic regions. Epigenetic mechanisms inform our understanding of gene transcriptional regulation, and alterations in the epigenome can occur during diseases such as cancer.

In a study by Liu et. al., 2025, Nat. Commun., Hi-C was used to assay the chromatin conformation changes during ionizing radiation-induced tumorigenesis. The authors performed Hi-C on a human bronchial epithelial cell line, BEP2D, and two radiation-induced tumour cell lines derived from BEP2D cells, BERP35T1 and BERP35T4. They identified widespread chromatin conformation alterations in the transformed cell lines compared to the BEP2D cells.

In our report, we have analysed the publicly available Hi-C dataset (GSE175860) to explore chromatin conformation changes between these cell lines.

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