Our experience in cell and gene therapy research spans from analysis of public datasets relevant to therapies in development, to investigation of off-target effects. In fact, Fios Genomics bioinformatics solutions have supported numerous clients developing therapies targeting neurodegenerative disorders, hearing loss, pain and more.
How We Can Help Your Research
By combining our expertise in bioinformatics analysis with our extensive knowledge in cell and gene therapy development, we can support your research in both pre-clinical and clinical stages. Some of our bioinformatics solutions for cell and gene therapy research include:
In silico solutions:
- Target identification
- On-target/off-tumour & off-target predictions
- Model selection: in vitro, in vivo, donor cell
- Design support for gene editing tools and experimental approach
Validation solutions:
- Product characterisation
- Clonotyping
- Insertion site analysis & vector copy number
- Immune cell profiling
- Molecular signature
- Mode of action & biological pathway analysis
Translation solutions:
- Precision medicine
- Biomarker prediction
- Patient stratification
Projects we have supported:
- Landscaping of public domain for data sets related to our clients’ targets of interest, to identify non-coding RNA associated with their target genes
- Analysis of differentially expressed genes (DEGs) to identify statistically significant changes (across specific comparisons confidential to the client) for a client developing an AAV gene therapy
- Mining and analysis of public data sets to identify gene and/or pathway overlaps relevant to our clients’ therapy research
- Mining public domain data to identify potential off-target sites for a client’s gene therapy
Make the FDA happy with ISA and VCN Assessment
If you are using integrative viral vectors at any stage of cell therapy development, we can help you enhance your products’ safety, by using bioinformatics to validate vector copy number and insertion sites. This approach ensures regulatory compliance, biosafety assessment, and detailed
product characterisation (through clonal tracking). Correlating the insertion sites with pre-clinical or trial response data can support the development of more effective and reliable therapies.
Whitepaper: Advancing Cell and Gene Therapy Research with Bioinformatics
This whitepaper explores the applications of bioinformatics in cell and gene therapy research, spanning from Antisense Oligonucleotide (ASO) research to T-cell expansion. Have a look to find out if there is a gap in your research or an easier way to find information your therapy relies on.
Benefits of working with Fios Genomics:
Dedicated Bioinformatician
A dedicated bioinformatician, backed by an experienced bioinformatics team, will curate all data, identify the most appropriate statistical approach to take and provide a biological interpretation of results
Interactive Data Analysis Report
Receive a searchable data analysis report that includes interactive visualisations of the data. Our reports are internally peer-reviewed and include analysis methods and results (particularly helpful if you plan to publish your research results)
Post-Report Follow-Up
Upon receipt of our data analysis report, we arrange a review call so that your project’s dedicated bioinformatician can talk you through the results and answer any questions you have about the report
Dedicated Project Manager
Your dedicated Project Manager will act as your single point of contact throughout the project. They will ensure everything from data transfer to report delivery runs smoothly and efficiently for you
Large Capacity Computing
When you choose Fios Genomics, you benefit from our large capacity computing and secure data storage facilities, where we store all your raw data, analysed data and your data analysis report
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