ScaleBio QuantumScale Data Analysis Service

30th March 2026
Posted by: Breige McBride
Categories: Bioinformatics, Single Cell Analysis

Scale Biosciences’ QuantumScale enables researchers to profile cells economically at scale (up to 4 million cells in a single run). However, the resulting data volume presents a significant computational hurdle. As studies move to a million-cell scale, the bioinformatics requirement shifts from standard processing to specialised, high-performance analysis.

More Data = More Complexity

With the complexity resulting from such an increase in data, expert bioinformatics analysis is essential. Fios Genomics performs robust analyses to provide confidence in your data, and a full write-up of findings to enable biological interpretation of statistical outcomes.

Alongside our partners at Concept Life Sciences, who generate scRNAseq data using QuantumScale, we support clients with in-depth quality control and read depth optimisation; high dimensional cell clustering and association testing for complex screens.

ScaleBio QuantumScale Data Analysis From Fios Genomics

Our Specialised ScaleBio QuantumScale Data Analysis Service includes:

QC & Read Depth Optimisation

We ensure your Quantum Barcoding was successful by validating:

Cell Recovery Rates: We ensure cell recovery matches the expected levels based on the initial input of cells.
Reads Per Cell: We assess sequencing depth to ensure sufficient reads per cell for robust downstream analysis.
Multiplexing Check: We evaluate the barcode demultiplexing efficiency and estimate multiplet rates to ensure they remain within the recommended thresholds.

High Dimensional Cell Clustering

With millions of cells, rare populations (the “needle in the haystack”) become statistically significant. Our team uses high-performance clustering as well as manual and automated cell type annotation methods to identify and annotate:

Sub-populations across multiple cell types and conditions.
Lineage trajectories in large-scale developmental or cancer models.

Association Testing for Complex Screens

The power of QuantumScale lies in its ability to run thousands of conditions. We provide:

Treatment vs. Control Analysis: Differential expression testing tailored for massive sample multiplexing.
Per-Cell-Type Sensitivity: Assessing how a drug or CRISPR perturbation affects specific lineages differently.

Robust Computational Infrastructure

As a leading bioinformatics provider, we have the high-capacity computational infrastructure necessary for managing large datasets, like those generated by QuantumScale. We also provide secure data storage, storing all raw data and processed outputs in your secure data analysis report, accessible via a password-protected HTML link.

Scale scRNAseq Insights to Move Your Research Forward

The transition to “Single-Cell at Scale” is an exciting leap forward for drug discovery and clinical research. However, the technology is only as powerful as the analysis behind it. By pairing the high throughput of ScaleBio with the analytical expertise of Fios Genomics, you will uncover the most valuable insights from your scRNAseq data to advance your research.

Ready to scale your next project? Use the form below to tell us about it and we’ll be happy to advise about our ScaleBio QuantumScale data analysis service and how we can support you.

QuantumScale is a Scale Biosciences product. Fios Genomics provides independent data analysis services for researchers using this platform.

Author: Breige McBride, Marketing Manager, Fios Genomics
Reviewed by Fios Genomics Bioinformatics Experts to ensure accuracy